As concerns the local diffusion of VOCs in Italy according to ISS data, variants bearing the D614G mutation have replaced the prototype Wuhan strain between April and May 2020, the alpha (B1.1.7) variant has become largely prevalent (over 80% of COVID-19 cases) between February and March 2021, whilst the prevalence of the delta variant (B.1.617.2) has displayed a dramatic increase in May/June 2021. Irrespective of this evolving epidemiological trend, the normalized GTS of the four symptoms has followed a virtually overlapping trend over time, without exhibiting substantial differences (Figure 1). The absence of a time-dependent variation in the prevalence of COVID-19 symptoms is reflected by highly significant Spearman's correlations among all normalized GTS for all symptoms (all r≥0.94 and p<0.001).
Is diffusion of SARS-CoV-2 variants of concern associated with different symptoms?
Mattiuzzi, Camilla;Lippi, Giuseppe
2022-01-01
Abstract
As concerns the local diffusion of VOCs in Italy according to ISS data, variants bearing the D614G mutation have replaced the prototype Wuhan strain between April and May 2020, the alpha (B1.1.7) variant has become largely prevalent (over 80% of COVID-19 cases) between February and March 2021, whilst the prevalence of the delta variant (B.1.617.2) has displayed a dramatic increase in May/June 2021. Irrespective of this evolving epidemiological trend, the normalized GTS of the four symptoms has followed a virtually overlapping trend over time, without exhibiting substantial differences (Figure 1). The absence of a time-dependent variation in the prevalence of COVID-19 symptoms is reflected by highly significant Spearman's correlations among all normalized GTS for all symptoms (all r≥0.94 and p<0.001).
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