Elevated fasting plasma glucose has been associated with increased risk for development of type 2 diabetes (T2D). The balance between glucokinase (GCK) and glucose-6-phosphate catalytic subunit 2 (G6PC2) activity are involved in glucose homeostasis through glycolytic flux, and subsequent insulin secretion.

Haplotypes of the genes (GCK and G6PC2) underlying the glucose/glucose-6-phosphate cycle are associated with pancreatic beta cell glucose sensitivity in patients with newly diagnosed type 2 diabetes from the VNDS study (VNDS 11)

Zusi, C;Rinaldi, E;Bonetti, S;Boselli, M L;Trabetti, E;Malerba, G;Bonora, E;Trombetta, M
2021

Abstract

Elevated fasting plasma glucose has been associated with increased risk for development of type 2 diabetes (T2D). The balance between glucokinase (GCK) and glucose-6-phosphate catalytic subunit 2 (G6PC2) activity are involved in glucose homeostasis through glycolytic flux, and subsequent insulin secretion.
Beta-cell function
Fasting plasma glucose
G6PC2
GCK
Haplotypes
SNP
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1044949
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