Health concerns associated with the exposure to legacy perfluoro-alkyl substances (PFAS) led to the development of new-generation PFAS, such as C6O4. Here we investigated the possible effects of C6O4 on the platelet's activation profile, by incubating human platelets from healthy donors with C6O4 at different concentrations and evaluating the effects on activation, production and phenotype of platelets micro-particles (MPV) and aggregation under-flow. Based on the eventual platelet pro-aggregation profile detected, the preventive effect of acetylsalicylic acid (ASA) was also explored.

Interference of C6O4 on platelet aggregation pathways: Cues on the new-generation of perfluoro-alkyl substance

Minuz, Pietro;Castelli, Marco;Meneguzzi, Alessandra;
2021

Abstract

Health concerns associated with the exposure to legacy perfluoro-alkyl substances (PFAS) led to the development of new-generation PFAS, such as C6O4. Here we investigated the possible effects of C6O4 on the platelet's activation profile, by incubating human platelets from healthy donors with C6O4 at different concentrations and evaluating the effects on activation, production and phenotype of platelets micro-particles (MPV) and aggregation under-flow. Based on the eventual platelet pro-aggregation profile detected, the preventive effect of acetylsalicylic acid (ASA) was also explored.
Acetylsalicylic acid
Cardiovascular risk
Flow cytometry
Platelets micro-particles
Toxicokinetics
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/1044559
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