In the colonic environment, sustained Wnt–β-catenin activation in regulatory T cells promotes epigenetic rewiring toward proinfammatory RORγt + Treg cells, whose expansion parallels the disease progression from infammatory bowel disease (IBD) to manifest colorectal cancer (CRC).

Wnt–β-catenin as an epigenetic switcher in colonic Treg cells

Canè S;Bronte V
2021

Abstract

In the colonic environment, sustained Wnt–β-catenin activation in regulatory T cells promotes epigenetic rewiring toward proinfammatory RORγt + Treg cells, whose expansion parallels the disease progression from infammatory bowel disease (IBD) to manifest colorectal cancer (CRC).
B catenin, Tregs, epigenetic
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/1043280
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