Bimetallic nanoparticles allow new and synergistic properties compared to the monometallic equivalents, often leading to unexpected results. Here we present on silver-iron nanoparticles coated with polyethylene glycol, which exhibit a high transverse relaxivity (316 ± 13 mM-1s-1, > 3 times that of the most common clinical benchmark based on iron oxide), excellent colloidal stability and biocompatibility in vivo. Ag-Fe nanoparticles are obtained through a one-step, low-cost laser-assisted synthesis, which makes surface functionalization with the desired biomolecules very easy. Besides, Ag-Fe nanoparticles show biodegradation over a few months, as indicated by incubation in the physiological environment. This is crucial for nanomaterials removal from the living organism and, in fact, in vivo biodistribution studies evidenced that Ag-Fe nanoparticles tend to be cleared from liver over a period in which the benchmark iron oxide contrast agent persisted. Therefore, the Ag-Fe NPs offer positive prospects for solving the problems of biopersistence, contrast efficiency, difficulties of synthesis and surface functionalization usually encountered in nanoparticulate contrast agents.
|Titolo:||Polymer-coated silver-iron nanoparticles as efficient and biodegradable MRI contrast agents|
MARZOLA, Pasquina (Corresponding)
|Data di pubblicazione:||2021|
|Appare nelle tipologie:||01.01 Articolo in Rivista|