In this prospective study, we observed that Ang-2 levels measured at ED presentation are significantly increased in patients at risk of developing severe AKI. Moreover, we observed that elevated Ang-2 is an independent predictor of severe AKI and RRT. Overall, our results are consistent with a picture of endothelial injury and a thrombotic microangiopathy phenomenon in COVID-19-associated AKI, further supported by the negative correlation with ADAMTS13 activity and positive correlations with fibrinogen and D-dimer. These results are consistent with elevations of Ang-2 observed in other forms of TMA. Future longitudinal studies are needed to fully elucidate the role of Ang-2 in COVID-19 endothelial dysfunction and multiorgan injury and the specificity of Ang-2 for COVID-19 AKI.
Circulating level of Angiopoietin-2 is associated with acute kidney injury in coronavirus disease 2019 (COVID-19)
Lippi, Giuseppe;
2021-01-01
Abstract
In this prospective study, we observed that Ang-2 levels measured at ED presentation are significantly increased in patients at risk of developing severe AKI. Moreover, we observed that elevated Ang-2 is an independent predictor of severe AKI and RRT. Overall, our results are consistent with a picture of endothelial injury and a thrombotic microangiopathy phenomenon in COVID-19-associated AKI, further supported by the negative correlation with ADAMTS13 activity and positive correlations with fibrinogen and D-dimer. These results are consistent with elevations of Ang-2 observed in other forms of TMA. Future longitudinal studies are needed to fully elucidate the role of Ang-2 in COVID-19 endothelial dysfunction and multiorgan injury and the specificity of Ang-2 for COVID-19 AKI.
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