The current management guidelines recommend that patients with borderline resectable pancreatic adenocarcinoma (BRPC) should initially receive neoadjuvant chemotherapy. The addition of advanced radiation therapy modalities, including stereotactic body radiation therapy (SBRT) and intraoperative radiation therapy (IORT), could result in a more effective neoadjuvant strategy, with higher rates of margin-free resections and improved survival outcomes.

A phase II trial proposal of total neoadjuvant treatment with primary chemotherapy, stereotactic body radiation therapy, and intraoperative radiation therapy in borderline resectable pancreatic adenocarcinoma

Paiella, Salvatore;Malleo, Giuseppe;Guariglia, Stefania;Cavedon, Carlo;Marchegiani, Giovanni;Esposito, Alessandro;Landoni, Luca;Casetti, Luca;Milella, Michele;Secchettin, Erica;Manzini, Gessica;Bovo, Chiara;De Pastena, Matteo;Fontana, Martina;Salvia, Roberto;Mazzarotto, Renzo;Bassi, Claudio
2021-01-01

Abstract

The current management guidelines recommend that patients with borderline resectable pancreatic adenocarcinoma (BRPC) should initially receive neoadjuvant chemotherapy. The addition of advanced radiation therapy modalities, including stereotactic body radiation therapy (SBRT) and intraoperative radiation therapy (IORT), could result in a more effective neoadjuvant strategy, with higher rates of margin-free resections and improved survival outcomes.
Intraoperative radiotherapy (IORT)
Locally advanced pancreatic cancer
Neoadjuvant therapy
Pancreatic cancer
Stereotactic body radiation therapy (SBRT)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1036944
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