AIM:To analyze the correlation between preexisting comorbidity and other clinicopathological features, short-term surgical outcome and long-term survival in elderly patients with colorectal cancer (CRC).METHODS: According to age, 403 patients operated on for CRC in our department were divided into group A (< 70 years old) and group B (>= 70 years old) and analyzed statistically.RESULTS: Rectal localization prevailed in group A (31.6% vs 19.7%, P = 0.027), whereas the percentage of R0 resections was 77% in the two groups. Comorbidity rate was 46.2% and 69.1% for group A and B, respectively (P < 0.001), with a huge difference as regards cardiovascular diseases. Overall, postoperative morbidity was 16.9% and 20.8% in group A and B, respectively (P = 0.367), whereas mortality was limited to group B (4.5%, P = 0.001). In both groups, patients who suffered from postoperative complications had a higher overall comorbidity rate, with preexisting cardiovascular diseases prevailing in group B (P = 0.003). Overall 5-year survival rate was significantly better for group A (75.2% vs 55%, P = 0.006), whereas no significant difference was observed considering disease-specific survival (76.3% vs 76.9%, P = 0.674).CONCLUSION: In spite of an increase in postoperative mortality and a lower overall long-term survival for patients aged >= 70 years old, it should be considered that, even in the elderly group, a significant number of patients is alive 5 years after CRC resection. (C) 2009 The WJG Press and Baishideng. All rights reserved.

Impact of age-related comorbidity on results of colorectal cancer surgery

Pedrazzani, Corrado
;
2009-01-01

Abstract

AIM:To analyze the correlation between preexisting comorbidity and other clinicopathological features, short-term surgical outcome and long-term survival in elderly patients with colorectal cancer (CRC).METHODS: According to age, 403 patients operated on for CRC in our department were divided into group A (< 70 years old) and group B (>= 70 years old) and analyzed statistically.RESULTS: Rectal localization prevailed in group A (31.6% vs 19.7%, P = 0.027), whereas the percentage of R0 resections was 77% in the two groups. Comorbidity rate was 46.2% and 69.1% for group A and B, respectively (P < 0.001), with a huge difference as regards cardiovascular diseases. Overall, postoperative morbidity was 16.9% and 20.8% in group A and B, respectively (P = 0.367), whereas mortality was limited to group B (4.5%, P = 0.001). In both groups, patients who suffered from postoperative complications had a higher overall comorbidity rate, with preexisting cardiovascular diseases prevailing in group B (P = 0.003). Overall 5-year survival rate was significantly better for group A (75.2% vs 55%, P = 0.006), whereas no significant difference was observed considering disease-specific survival (76.3% vs 76.9%, P = 0.674).CONCLUSION: In spite of an increase in postoperative mortality and a lower overall long-term survival for patients aged >= 70 years old, it should be considered that, even in the elderly group, a significant number of patients is alive 5 years after CRC resection. (C) 2009 The WJG Press and Baishideng. All rights reserved.
2009
Colorectal cancer
Elderly
Post-operative complications
Co-morbidity
Aged
Adult
Age Factors
Aged
Aged, 80 and over
Comorbidity
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Postoperative Complications
Survival Rate
Treatment Outcome
Young Adult
Colorectal Neoplasms
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1029685
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