This protocol is a procedure for generating orthotopic isografts using mouse pancreatic cancer organoids. These isografts can be used to track the evolution of pancreatic ductal adenocarcinoma (PDA) from a preinvasive lesion to a metastatic disease and therefore represent a suitable model for identification of determinants of PDA progression. For complete details on the use and execution of this protocol, please refer to Boj et al. (2015) and Filippini et al. (2019).

Generation of Pancreatic Organoid-Derived Isografts

D'Agosto, Sabrina;Lupo, Francesca;Corbo, Vincenzo
2020-01-01

Abstract

This protocol is a procedure for generating orthotopic isografts using mouse pancreatic cancer organoids. These isografts can be used to track the evolution of pancreatic ductal adenocarcinoma (PDA) from a preinvasive lesion to a metastatic disease and therefore represent a suitable model for identification of determinants of PDA progression. For complete details on the use and execution of this protocol, please refer to Boj et al. (2015) and Filippini et al. (2019).
2020
pancreatic ductal adenocarcinoma (PDA)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1028251
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