Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral drugs with high virologic efficacy and excellent tolerability. Recent evidence showed a possible link of dolutegravir-based regimens with weight gain, and a relationship between raltegravir use and changes in adipose tissue density and metabolic abnormalities, with an increased cardiovascular risk, has been suggested. We describe a case where dolutegravir monotherapy led to a decrease in adipose tissue density.
Increase in visceral adipose tissue in a woman living with HIV after introduction of integrase strand transfer inhibitor
Piacentini, Daniela;Lanzafame, Massimiliano
;Rizzardo, Sebastiano;Chiesi, Sheila;Lattuada, Emanuela;Mehrabi, Sara;Zamboni, Giulia;Tacconelli, Evelina;Vento, Sandro
2020-01-01
Abstract
Integrase strand transfer inhibitors (INSTIs) are a class of antiretroviral drugs with high virologic efficacy and excellent tolerability. Recent evidence showed a possible link of dolutegravir-based regimens with weight gain, and a relationship between raltegravir use and changes in adipose tissue density and metabolic abnormalities, with an increased cardiovascular risk, has been suggested. We describe a case where dolutegravir monotherapy led to a decrease in adipose tissue density.
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