Although further evidence, based on solid cost-effectiveness analyses, would be needed to make definitive conclusions on this matter, it is undeniable that routine D-dimer measurement may currently help identifying a subset of COVID-19 patients at enhanced risk of unfavorable progression, who may then benefit from more extensive assessment and tailored treatment. The ideal cut-off for use in patient stratification needs more definitive investigation, and may differ according to the method used. In theory, there are also 28 possible reporting units for D-dimer, though the number is likely closer to 5 for units preferred by the major D-dimer manufacturers. Irrespective, D-dimer reporting in the COVID-19 era remains problematic, and we hope that future studies will clearly identify what methods and units are being reported, in order to enable clearer comparison of findings.

D-dimer measurement in COVID-19: Silver bullet or clinical distraction?

Lippi, Giuseppe
;
2020

Abstract

Although further evidence, based on solid cost-effectiveness analyses, would be needed to make definitive conclusions on this matter, it is undeniable that routine D-dimer measurement may currently help identifying a subset of COVID-19 patients at enhanced risk of unfavorable progression, who may then benefit from more extensive assessment and tailored treatment. The ideal cut-off for use in patient stratification needs more definitive investigation, and may differ according to the method used. In theory, there are also 28 possible reporting units for D-dimer, though the number is likely closer to 5 for units preferred by the major D-dimer manufacturers. Irrespective, D-dimer reporting in the COVID-19 era remains problematic, and we hope that future studies will clearly identify what methods and units are being reported, in order to enable clearer comparison of findings.
COVID-19, Coronavirus, D-dimer, Prognosis
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11562/1027339
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