In Vivo Immunomodulatory Potential of Partial Purified Lectin from the Saffron Milk Cap Mushroom, Lactarius deliciosus (Agaricomycetes), against Colloidal Carbon Particles

Mushrooms compounds and biomolecules are known for their biological beneficial effect and dietary properties. Theirs molecules are using at immunology for the ability to stimulate immune cells and biotherapy of diseases. In this study, the immunomodulatory effect using carbon clearance test in vivo of partial purified lectins of Lactarius deliciosus using DEAE-Sephacyl column, with sugar affinity against galactose, methyl-B.D galactopyranoside and lactose, specify showed a significant effect on phagocytic activity and half time of life of carbon particles in mice with different concentrations (5, 10, 15 and 30mg/kg). The results showed that: the immunomodulatory effect increased in low doses and decreased after in high doses as compared with the control group p< 0.0001. L. deliciosus lectin exerted a dose-dependent immunostimulant activity at the reticulo-endothelial system, phagocytic activity on macrophages and neutrophils in spleen and liver against the carbon colloidal.