Maternal and Perinatal Outcomes of Pregnant Women with SARS-COV-2 infection

Gabriele Saccone MD,; Cihat Sen MD,; Daniele Di Mascio MD,; Alberto Galindo MD,; Amos Grünebaum MD,; Jun Yoshimatsu MD,; Milan Stanojevic MD,; Asım Kurjak MD,; Frank Chervenak MD,; María José Rodríguez Suárez MD,; Zita Maria Gambacorti-Passerini MD,; María de los Angeles Anaya Baz MD,; Esther Vanessa Aguilar Galán MD,; Yolanda Cuñarro López MD,; Juan Antonio De León Luis MD,; Ignacio Cueto Hernández MD,; Ignacio Herraiz MD,; Cecilia Villalain MD,; Roberta Venturella MD,; Giuseppe Rizzo MD,; Ilenia Mappa MD,; Giovanni Gerosolima MD,; Lars Hellmeyer MD,; Josefine Königbauer MD,; Giada Ameli MD,; Tiziana Frusca MD,; Nicola Volpe MD,; Giovanni Battista Luca Schera MD,; Stefania Fieni MD,; Eutalia Esposito MD,; Giuliana Simonazzi MD,; Gaetana Di Donna MD,; Aly Youssef MD,; Anna Nunzia Della Gatta MD,; Mariano Catello Di Donna MD,; Vito Chiantera MD,; Natalina Buono MD,; Giulio Sozzi MD,; Pantaleo Greco MD,; Danila Morano MD,; Beatrice Bianchi MD,; Maria Giulia Lombana Marino MD,; Federica Laraud MD,; Arianna Ramone MD,; Angelo Cagnacci MD,; Fabio Barra MD,; Claudio Gustavino MD,; Simone Ferrero MD,; Fabio Ghezzi MD,; Antonella Cromi MD,; Antonio Simone Laganà MD,; Valentina Laurita Longo MD,; Francesca Stollagli MD,; Angelo Sirico MD,; Antonio Lanzone MD,; Lorenza Driul MD,; Fabiana Cecchini MD,; Serena Xodo MD,; Brian Rodriguez MD,; Felipe Mercado-Olivares MD,; Deena Elkafrawi MD,; Giovanni Sisti MD,; Rosanna Esposito MD,; Antonio Coviello MD,; Marco Cerbone MD,; Maddalena Morlando MD,; Schiattarella, Antonio; Nicola Colacurci MD,; Pasquale De Franciscis MD,; Ilaria Cataneo MD,; Lenzi, Marinella; Fabrizio Sandri MD,; Riccardo Buscemi MD,; Giorgia Gattei MD,; Francesca della Sala MD,; Leonardo Gucciardo MD,; Valentina Esposito MD,; Flaminia Vena MD,; Antonella Giancotti MD,; Roberto Brunelli MD,; Ludovico Muzii MD,; Luigi Nappi MD,; Felice Sorrentino MD,; Marco Liberati MD,; Danilo Buca MD,; Leombroni, Martina; Md,; Francesca Di Sebastiano MD,; Franchi, Massimo; Ianniciello, QUINTINO CESARE; Garzon, Simone; Eleonora Valori MD,; Giuliano Petriglia MD,; Leonardo Borrello MD,; Albaro Josè Nieto-Calvache MD,; Juan Manuel Burgos-Luna MD,; Caroline Kadji MD,; Andrew Carlin MD,; Bevilacqua, Elisa; Maria Cristina Rovellotti MD,; Elisa Done MD,; Gilles Faron MD,; Marina Moucho MD,; Pedro Viana Pinto MD,; Rita Figueiredo MD,; José Morales Roselló MD,; Gabriela Loscalzo MD,; Alicia Martinez-Varea MD,; Vincente Diago MD,; Jesús, S Jimenez Lopez MD; Alicia Yeliz Aykanat MD,; Stefano Cosma MD,; Andrea Carosso MD,; Chiara Benedetto MD,; Amanda Bermejo MD,; Otto Henrique May Feuerschuette MD,; Ozlem Uyaniklar MD,; Sakine Rahimli Ocakouglu MD,; Zeliha Atak MD,; Reyhan Gündüz MD,; Esra Tustas Haberal MD,; Bernd Froessler MD,; Anupam Parange MD,; Peter Palm MD,; Igor Samardjiski MD,; Chiara Taccaliti MD,; Erhan Okuyan MD,; George Daskalakis MD,; Renato Augusto Moreira de Sa MD,; Alejandro Pittaro MD,; Maria Luisa Gonzalez-Duran MD,; Ana Concheiro Guisan MD,; Şerife Özlem Genç MD,; Blanka Zlatohlávková MD,; Anna Luengo Piqueras MD,; Dolores Esteban Oliva MD,; Aylin Pelin Cil MD,; Olus Api MD,; Panos Antsaklis MD,; Liana Ples MD,; Ioannis Kyvernitakis MD,; Holger Maul MD,; Marcel Malan MD,; Albert Lila MD,; Roberta Granese MD,; Alfredo Ercoli MD,; Giuseppe Zoccali MD,; Andrea Villasco MD,; Nicoletta Biglia MD,; Ciuhodaru Madalina MD,; Elena Costa MD,; Caroline Daelemans MD,; Axelle Pintiaux MD,; Elif Gül Yapar Eyi MD,; Elisa Cueto MD,; Eran Hadar MD,; Sarah Dollinger MD,; Brzezinski-Sinai MD, Noa A.; Erasmo Huertas MD,; Pedro Arango MD,; Amadeo Sanchez MD,; Javier Alfonso Schvartzman MD,; Liviu Cojocaru MD,; Sifa Turan MD,; Ozhan Turan MD,; Maria Carmela Di Dedda MD,; Rebeca Garrote Molpeceres MD,; Snezana Zdjelar MD,; Tanja Premru-Srsen MD,; Lilijana Kornhauser-Cerar MD,; Mirjam Druškovič MD,; Valentina De Robertis MD,; Vedran Stefanovic MD,; Irmeli Nupponen MD,; Kaisa Nelskylä MD,; Zulfiya Khodjaeva MD,; Gorina MD, Ksenia A.; Sukhikh MD, Gennady T.; Giuseppe Maria Maruotti MD,; Silvia Visentin MD,; Erich Cosmi MD,; Jacopo Ferrari MD,; Alessandra Gatti MD,; Daniela Luvero MD,; Roberto Angioli MD,; Ludovica Puri MD,; Marco Palumbo MD,; Giusella D’Urso MD,; Francesco Colaleo MD,; Agnese Maria Chiara Rapisarda MD,; Ilma Floriana Carbone MD,; Lamberto Manzoli MD,; Maria Elena Flacco MD,; Giovanni Nazzaro MD,; Mariavittoria Locci MD,; Maurizio Guida MD,; Attilio Di Spiezio Sardo MD,; Pierluigi Benedetti Panici MD,; Asma Khalil MD,; Vincenzo Berghella MD,; Giuseppe Bifulco MD,; Giovanni Scambia MD,; Fulvio Zullo MD,; Francesco D’Antonio MD,

doi:10.1002/uog.23107

OBJECTIVES:To evaluate maternal and perinatal outcomes of pregnant women affected by SARS-COV-2. METHODS:This was a multinational retrospective cohort study including women with laboratory-confirmed SARS-COV-2 from 73 centers from 22 different countries in Europe, United States, South America, Asia and Australia from February 1, 2020 to April 30, 2020. Confirmed SARS-COV-2 infection was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity including admission to intensive care unit (ICU), use of mechanical ventilation, or death. RESULTS:388 singleton pregnancies tested positive to SARS-COV-2 at RT-PCR nasal and pharyngeal swab were included in the study. The primary outcome was observed in 47/388 women (12.1%). 43/388 women (11.1%) were admitted to ICU, 36/388 (9.3%) required mechanical ventilation, and 3/388 women deceased (0.8%). Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of the study. Among the other 266 women, 6 had spontaneous first-trimester abortion, 3 had elective termination of pregnancy, 6 had stillbirth, and 251 delivered a live-born infant. The rate of preterm birth less than 37 weeks of gestation was 26.3% (70/266). Of the 251 live-born infants, 69/251 (27.5%) were admitted to NICU, with 5 neonatal deaths (2.0%). The overall rate of perinatal death was 4.1% (11/266). Only one infant (1/251, 0.4%) born from a mother tested positive during the third trimester, was found positive to SARS-COV-2 at RT-PCR. CONCLUSIONS:SARS-COV-2 in pregnant women is associated with 0.8% rate of maternal mortality, but 11.1% rate of admission to ICU. The risk of vertical transmission seems to be negligible. This article is protected by copyright. All rights reserved.