In this study, we present findings of low levels of Ang1,7 in patients with COVID-19 as compared to healthy controls. Moreover, we observed lower levels of Ang1, which suggests that the RAAS system may be relatively suppressed in patients with COVID-19. This may be due to low plasma renin activity or decreased angiotensinogen levels, which should be measured in future studies. As ACE2 activity may be attenuated by SARS-CoV-2 binding, the Ang1 may therefore be mostly metabolized via ACE, thus generating an adequate amount of Ang2, as previously observed, along with the low Ang1,7 levels presented in this report. Further investigations measuring ACE2 levels and ACE2 activity are needed to fully interpret these findings.
Coronavirus Disease 2019 (COVID-19) is Associated with Low Circulating Plasma Levels of Angiotensin 1 and Angiotensin 1,7
Lippi, Giuseppe;
2021-01-01
Abstract
In this study, we present findings of low levels of Ang1,7 in patients with COVID-19 as compared to healthy controls. Moreover, we observed lower levels of Ang1, which suggests that the RAAS system may be relatively suppressed in patients with COVID-19. This may be due to low plasma renin activity or decreased angiotensinogen levels, which should be measured in future studies. As ACE2 activity may be attenuated by SARS-CoV-2 binding, the Ang1 may therefore be mostly metabolized via ACE, thus generating an adequate amount of Ang2, as previously observed, along with the low Ang1,7 levels presented in this report. Further investigations measuring ACE2 levels and ACE2 activity are needed to fully interpret these findings.
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