COVID-19 patients develop pneumonia generally associated to lymphopenia and severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK-STAT signaling pathways, which can be disabled by small molecules.

Baricitinib restrains the immune dysregulation in severe COVID-19 patients

Bronte, Vincenzo
;
Ugel, Stefano;Tinazzi, Elisa;Vella, Antonio;De Sanctis, Francesco;Canè, Stefania;Batani, Veronica;Trovato, Rosalinda;Fiore, Alessandra;Petrova, Varvara;Hofer, Francesca;Barouni, Roza Maria;Musiu, Chiara;Caligola, Simone;Pinton, Laura;Torroni, Lorena;Polati, Enrico;Donadello, Katia;Friso, Simonetta;Pizzolo, Francesca;Comel, Andrea C;Lunardi, Claudio;Olivieri, Oliviero
2020

Abstract

COVID-19 patients develop pneumonia generally associated to lymphopenia and severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK-STAT signaling pathways, which can be disabled by small molecules.
COVID-19; Immunology; Innate immunity
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1023443
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