COVID-19 patients develop pneumonia generally associated to lymphopenia and severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK-STAT signaling pathways, which can be disabled by small molecules.
Baricitinib restrains the immune dysregulation in patients with severe COVID-19
Bronte, Vincenzo
;Ugel, Stefano;Tinazzi, Elisa;Vella, Antonio;De Sanctis, Francesco;Canè, Stefania;Batani, Veronica;Trovato, Rosalinda;Fiore, Alessandra;Petrova, Varvara;Hofer, Francesca;Barouni, Roza Maria;Musiu, Chiara;Caligola, Simone;Pinton, Laura;Torroni, Lorena;Polati, Enrico;Donadello, Katia;Friso, Simonetta;Pizzolo, Francesca;Comel, Andrea C;Lunardi, Claudio;Olivieri, Oliviero
2020-01-01
Abstract
COVID-19 patients develop pneumonia generally associated to lymphopenia and severe inflammatory response due to uncontrolled cytokine release. These mediators are transcriptionally regulated by the JAK-STAT signaling pathways, which can be disabled by small molecules.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
