CATALOGO DEI PRODOTTI DELLA RICERCA
IRIS è la soluzione IT che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per monitorare i risultati della ricerca, aumentarne la visibilità e allocare in modo efficace le risorse disponibili.
EnglishAcidosis of the tumor microenvironment leads to cancer invasion, progression and resistance to therapies. We present a biophysical model that describes how tumor cells regulate intracellular and extracellular acidity while they grow in a microenvironment characterized by increasing acidity and hypoxia. the model takes into account the dynamic interplay between glucose and O2 consumptionwithlactateandCO productionandconnectstheseprocessestoH+andHCO−fluxes 2 inside and outside cells. We have validated the model with independent experimental data and used it to investigate how and to which extent tumor cells can survive in adverse micro-environments characterized by acidity and hypoxia. the simulations show a dominance of the H+ exchanges in well-oxygenated regions, and of HCO− exchanges in the inner hypoxic regions where tumor cells are 3 known to acquire malignant phenotypes. the model also includes the activity of the enzyme carbonic Anhydrase 9 (CA9), a known marker of tumor aggressiveness, and the simulations demonstrate that CA9 acts as a nonlinear pHi equalizer at any O2 level in cells that grow in acidic extracellular environments.
| Titolo: | The control of acidity in tumor cells: a biophysical model |
| Autori: | CHIGNOLA, Roberto (Corresponding) |
| Data di pubblicazione: | 2020 |
| Rivista: | |
| Handle: | http://hdl.handle.net/11562/1022999 |
| Appare nelle tipologie: | 01.01 Articolo in Rivista |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| SciReports2020full.pdf | main text + supplementary information | Versione dell'editore |  | Open Access Visualizza/Apri |
http://hdl.handle.net/11562/1022999
Copyright © 2021