Mitotic perturbations frequently lead to chromosome mis-segregation that generates genome instability, thereby triggering tumor onset and/or progression. Error-free mitosis depends on fidelity-monitoring systems that ensure the temporal and spatial coordination of chromosome segregation. Recent investigations are focused on mitotic DNA damage response (DDR) and chromosome mis-segregations with the aim of developing more e

Depletion of trichoplein (TpMs) causes chromosome mis-segregation, DNA damage and chromosome instability in cancer cells.

Lauriola A;Guardavaccaro D;D'Arca D.
2020-01-01

Abstract

Mitotic perturbations frequently lead to chromosome mis-segregation that generates genome instability, thereby triggering tumor onset and/or progression. Error-free mitosis depends on fidelity-monitoring systems that ensure the temporal and spatial coordination of chromosome segregation. Recent investigations are focused on mitotic DNA damage response (DDR) and chromosome mis-segregations with the aim of developing more e
2020
Trichoplein, Chromosome, Cancer
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1020012
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