Various nutrients have been designated as antioxidants, with a possible effect on diseases from the likes of cancer. This is partly due to their effect on prostaglandins, thereby affecting local pathological metabolic acidosis. This paper aims to summarize the culprit pathophysiological mechanisms involved, with a focus on the bone microenvironment. The omega-6/omega-3 PUFA ratio, in particular, is investigated on its antioxidative effects, countering these pathways to fight disease. This feature is applied concerning its impact on health in general, with a particular focus on malignant bone metastasis.
Insights on dietary omega-6/omega-3 polyunsaturated fatty acid (PUFA) ratio in oxidative metabolic pathways of oncological bone disease and global health
Chirumbolo, Salvatore;
2021-01-01
Abstract
Various nutrients have been designated as antioxidants, with a possible effect on diseases from the likes of cancer. This is partly due to their effect on prostaglandins, thereby affecting local pathological metabolic acidosis. This paper aims to summarize the culprit pathophysiological mechanisms involved, with a focus on the bone microenvironment. The omega-6/omega-3 PUFA ratio, in particular, is investigated on its antioxidative effects, countering these pathways to fight disease. This feature is applied concerning its impact on health in general, with a particular focus on malignant bone metastasis.
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