Introduction: There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown. Method: We pooled studies from published literature to assess the association of a history of stroke with outcomes in patients with COVID-19. Results: A pooled analysis of 4 studies showed a ∼2.5-fold increase in odds of severe COVID-19. While a trend was observed, there was no statistically significant association of stroke with mortality in patients with COVID-19 infection. Discussion: Our findings are limited by a small number of studies and sample size. Conclusion: There is a ∼2.5-fold increase in odds of severe COVID-19 illness with a history of cerebrovascular disease.

Cerebrovascular disease is associated with an increased disease severity in patients with Coronavirus Disease 2019 (COVID-19): A pooled analysis of published literature

Lippi, Giuseppe;
2020-01-01

Abstract

Introduction: There is an urgent need to identify patients at high risk during the ongoing coronavirus disease (COVID-19) pandemic. Whether a history of stroke is associated with increased severity of disease or mortality is unknown. Method: We pooled studies from published literature to assess the association of a history of stroke with outcomes in patients with COVID-19. Results: A pooled analysis of 4 studies showed a ∼2.5-fold increase in odds of severe COVID-19. While a trend was observed, there was no statistically significant association of stroke with mortality in patients with COVID-19 infection. Discussion: Our findings are limited by a small number of studies and sample size. Conclusion: There is a ∼2.5-fold increase in odds of severe COVID-19 illness with a history of cerebrovascular disease.
2020
COVID-19; Cerebrovascular disease; Coronavirus
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1016271
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