Diabetes occurring as a direct consequence of loss of liver function is usually characterized by non-diabetic fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) levels and should regress after orthotopic liver transplantation (OLT). This observational, longitudinal study investigated the relationship between the time-courses of changes in all 3 direct determinants of glucose regulation, i.e., β-cell function, insulin clearance and insulin sensitivity, and diabetes regression after OLT.

Central role of the β-cell in driving regression of diabetes after liver transplantation in cirrhotic patients

Trombetta, Maddalena;Boselli, Maria Linda;Bonadonna, Riccardo C;
2019-01-01

Abstract

Diabetes occurring as a direct consequence of loss of liver function is usually characterized by non-diabetic fasting plasma glucose (FPG) and haemoglobin A1c (HbA1c) levels and should regress after orthotopic liver transplantation (OLT). This observational, longitudinal study investigated the relationship between the time-courses of changes in all 3 direct determinants of glucose regulation, i.e., β-cell function, insulin clearance and insulin sensitivity, and diabetes regression after OLT.
2019
Hepatogenous diabetes; Insulin resistance; Liver cirrhosis; Orthotopic liver transplantation; β-cell dysfunction
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1012877
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