We present an NMR method based on natural abundance O-17 relaxation of water to determine effective viscosity in biological aqueous samples. The method accurately captures viscosity of dilute and crowded protein solutions and offers a fairly simple way to quantify the internal fluidity of biological condensates formed through phase separation.
A facile oxygen-17 NMR method to determine effective viscosity in dilute, molecularly crowded and confined aqueous media
Munari, Francesca;Assfalg, Michael;
2019-01-01
Abstract
We present an NMR method based on natural abundance O-17 relaxation of water to determine effective viscosity in biological aqueous samples. The method accurately captures viscosity of dilute and crowded protein solutions and offers a fairly simple way to quantify the internal fluidity of biological condensates formed through phase separation.
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