The bla IMP gene was the first transferable metallo-β-lactamase determinant identified in clinical isolates of various Enterobacteriaceae (Serratia marcescens, Klebsiella pneumoniae, Citrobacter freundii), Pseudomonas aeruginosa, and other nonfastidious gram-negative non-fermenters . Owing to the broad substrate profile of its product (the IMP-1 enzyme), which includes expanded-spectrum cephalosporins and carbapenems, spreading of bla IMP among similar pathogens is a matter of major concern for the future of antimicrobial chemotherapy. Thus far Thus far the bla IMP determinant has been detected in oonly clinical isolates from Japan and South Korea, while metallo-carbapenemase-producing P aeruginosastrains occasionally isolated in Europe have been found to harbour determinants other than bla IMP
Appearance of IMP-1 metallo-β-lactamase in Europe
Cornaglia, G;Mazzariol, A;Fontana, R;
1999-01-01
Abstract
The bla IMP gene was the first transferable metallo-β-lactamase determinant identified in clinical isolates of various Enterobacteriaceae (Serratia marcescens, Klebsiella pneumoniae, Citrobacter freundii), Pseudomonas aeruginosa, and other nonfastidious gram-negative non-fermenters . Owing to the broad substrate profile of its product (the IMP-1 enzyme), which includes expanded-spectrum cephalosporins and carbapenems, spreading of bla IMP among similar pathogens is a matter of major concern for the future of antimicrobial chemotherapy. Thus far Thus far the bla IMP determinant has been detected in oonly clinical isolates from Japan and South Korea, while metallo-carbapenemase-producing P aeruginosastrains occasionally isolated in Europe have been found to harbour determinants other than bla IMP
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