One of the most valuable innovations in the field of high-grade glioma (HGG) surgery is 5 aminolevulinic acid (5-ALA). Florescence is a specific and sensitive indicator of metabolically active tumoral tissue. In published literature the main focus was placed on false negative cases, with only few papers addressing the issue of false positivity. The aim of the paper is to highlight those settings in which 5-ALA flourescence does not necessarily mean tumor, and to point out those conditions in which intraoperative 5-ALA fluorescence has to be critically considered.
5-Aminolevulinic Acid False Positives in Cerebral Neuro-Oncology: Not All That Is Fluorescent Is Tumor. A Case-Based Update and Literature Review
Barresi, Valeria;
2020-01-01
Abstract
One of the most valuable innovations in the field of high-grade glioma (HGG) surgery is 5 aminolevulinic acid (5-ALA). Florescence is a specific and sensitive indicator of metabolically active tumoral tissue. In published literature the main focus was placed on false negative cases, with only few papers addressing the issue of false positivity. The aim of the paper is to highlight those settings in which 5-ALA flourescence does not necessarily mean tumor, and to point out those conditions in which intraoperative 5-ALA fluorescence has to be critically considered.
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