A persistent low inflammatory-oxidative status and the inadequacy of the antioxidant nuclear factor-E2-related factor 2 (Nrf2) have been implicated in chronic obstructive pulmonary disease (COPD) progression. Therefore this study was aimed to assess the association between lung function decline and oxidative-inflammatory markers and Nrf2 signaling pathway expression in peripheral blood mononuclear cells (PBMCs) over time.

Oxidative stress and Nrf2 expression in peripheral blood mononuclear cells derived from COPD patients: an observational longitudinal study

Fratta Pasini, A M;Stranieri, C;Garbin, U;Cazzoletti, L;Mozzini, C;Spelta, F;Peserico, D;Cominacini, L
2020-01-01

Abstract

A persistent low inflammatory-oxidative status and the inadequacy of the antioxidant nuclear factor-E2-related factor 2 (Nrf2) have been implicated in chronic obstructive pulmonary disease (COPD) progression. Therefore this study was aimed to assess the association between lung function decline and oxidative-inflammatory markers and Nrf2 signaling pathway expression in peripheral blood mononuclear cells (PBMCs) over time.
2020
COPD progression; Nrf2/ARE gene expression; Oxidative stress; PBMCs
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/1010409
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