Meningiomas represent frequent tumors mainly characterized by a benign histology and an indolent clinical course. The histological grade and extent of surgical resection are considered to be the most powerful prognosticators for these neoplasias. Nonetheless, a percentage of meningiomas do display relapses despite a total macroscopic resection, although the reasons of this phenomenon still remain to be fully clarified. Herein the prognostic value of angiogenesis and of the expression of its regulators in completely surgically resected meningiomas is discussed. In particular, the role of semaphorin3A (SEMA3A) in the regulation of angiogenesis and the correlation between its expression and the risk of recurrence of meningiomas are illustrated
Meningiomas: Role of Semaphorin3A Protein in Antiangiogenesis
Barresi V
2012-01-01
Abstract
Meningiomas represent frequent tumors mainly characterized by a benign histology and an indolent clinical course. The histological grade and extent of surgical resection are considered to be the most powerful prognosticators for these neoplasias. Nonetheless, a percentage of meningiomas do display relapses despite a total macroscopic resection, although the reasons of this phenomenon still remain to be fully clarified. Herein the prognostic value of angiogenesis and of the expression of its regulators in completely surgically resected meningiomas is discussed. In particular, the role of semaphorin3A (SEMA3A) in the regulation of angiogenesis and the correlation between its expression and the risk of recurrence of meningiomas are illustrated
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