Cross-talk tra cellula adiposa e cellula neoplastica modelli di cocoltura

White adipose tissue (WAT) is considered as a complex organ with a central role in accumulation of lipids, and an important endocrine function with the secretion of several peptides as adipokines (leptin, adiponectin), cytokines and chemokines, tumor necrosis factor (TNF) and interleukin-6 (IL-6). Cancer is the leading cause of death in developed countries and the second leading cause of death in developing countries. The number of cancer cases is expected to rise due to the increasing aging population.