One-carbon metabolism ultimately delivers one-carbon moiety (methyl group) to many biologic reactions, including nucleotide synthesis and biological methylation, that are needed to synthesize essential components of cells and tissues and to maintain body homeostasis. One-carbon metabolism is also connected to other energy metabolisms. Thus, one-carbon metabolism is central to maintaining the integrity of human health and body repair. It is not surprising that altered one-carbon metabolism is highly associated with aging and age-associated diseases such as cancer, cardiovascular diseases, and neurocognitive diseases. Adequate balance of one-carbon metabolism through one-carbon nutrients, such as B-vitamins, methionine, and choline, is particularly important in human health

One-Carbon Metabolism: An Unsung Hero for Healthy Aging

FRISO, Simonetta
2016-01-01

Abstract

One-carbon metabolism ultimately delivers one-carbon moiety (methyl group) to many biologic reactions, including nucleotide synthesis and biological methylation, that are needed to synthesize essential components of cells and tissues and to maintain body homeostasis. One-carbon metabolism is also connected to other energy metabolisms. Thus, one-carbon metabolism is central to maintaining the integrity of human health and body repair. It is not surprising that altered one-carbon metabolism is highly associated with aging and age-associated diseases such as cancer, cardiovascular diseases, and neurocognitive diseases. Adequate balance of one-carbon metabolism through one-carbon nutrients, such as B-vitamins, methionine, and choline, is particularly important in human health
2016
9780128018163
Epigenetics, DNA methylation, folate, vitamin B12, vitamin B6, Aging; Cancer; Cardiovascular disease; Gene-nutrient interaction; Inflammation; Neurocognitive disease; One-carbon metabolism histone modification, post-translational histone modifications, smal non coding RNAs, microRNAs
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/953844
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