Drug-induced renal injury remains an important clinical problem in the newborn, particularly if preterm, and a prenatal exposure to drugs potentially nephrotoxic may influence renal function not only during pregnancy but also after birth. In this article, the pathophysiological role of some drugs taken during pregnancy has been discussed. In detail, the effects of antibacterials, NSAIDs, ACE-inhibitors and angiotensin II receptor antagonists on renal function have been analysed, reporting data available in the literature on the development of acute and long-term nephrotoxicity in the fetus and neonate: up to the present several cases of severe and sometimes irreversible renal insufficiency have been reported after prenatal exposure to these drugs.
Influence of prenatal drug treatments on kidney function during fetal and neonatal life
CUZZOLIN, Laura;
2012-01-01
Abstract
Drug-induced renal injury remains an important clinical problem in the newborn, particularly if preterm, and a prenatal exposure to drugs potentially nephrotoxic may influence renal function not only during pregnancy but also after birth. In this article, the pathophysiological role of some drugs taken during pregnancy has been discussed. In detail, the effects of antibacterials, NSAIDs, ACE-inhibitors and angiotensin II receptor antagonists on renal function have been analysed, reporting data available in the literature on the development of acute and long-term nephrotoxicity in the fetus and neonate: up to the present several cases of severe and sometimes irreversible renal insufficiency have been reported after prenatal exposure to these drugs.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
