In this paper we develop an application of the MP theory to gene expression analysis. After introducing some general concepts about transcriptome analysis and about gene networks, we delineate a methodology for modelling such kind of networks by means of Metabolic P systems. MP systems were initially introduced as models of metabolic processes, but they can be successfully used in each context where we want to infer models of a system from a given set of time series. In thecase of gene expression analysis, we found a standard way for translating MP grammars involving gene expressions into corresponding quantitative gene networks. Pre-processing methods of raw time series have been also elaborated in order to achieve a successful MP modelling of theunderlying gene network.
A Methodology Based on MP Theory for Gene Expression Analysis
MARCHETTI, Luca;MANCA, Vincenzo
2012-01-01
Abstract
In this paper we develop an application of the MP theory to gene expression analysis. After introducing some general concepts about transcriptome analysis and about gene networks, we delineate a methodology for modelling such kind of networks by means of Metabolic P systems. MP systems were initially introduced as models of metabolic processes, but they can be successfully used in each context where we want to infer models of a system from a given set of time series. In thecase of gene expression analysis, we found a standard way for translating MP grammars involving gene expressions into corresponding quantitative gene networks. Pre-processing methods of raw time series have been also elaborated in order to achieve a successful MP modelling of theunderlying gene network.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.