The main aim in treating mania, hypomania and mixed episodes is to achieve rapid control of symptoms. This is particularly important as mania can result in disturbed behavior that, when extreme, can be a risk to the safety of the patient and others. Mood stabilizers and antipsychotic agents have long been the mainstay of treatment of acute mania (with and without psychotic features). For clinical conditions where many treatment regimens already exist, competing with each other, the real question is how to rank their benefits (and harms) to choose the best option. This has led to the development of multiple treatments meta-analysis (MTM) that allow the incorporation of evidence from direct and indirect comparisons toward estimating summary treatment effects. The aim of this study is to compare the efficacy and acceptability of pharmacological treatments for acute mania, in order to inform clinical practice and mental health policies. We carried out a MTM. Reliable information on comparative efficacy is essential for informing clinical practice and policymaking and MTM allows us to use all the available evidence to estimate potential differences in efficacy among treatments.
COMPARATIVE EFFICACY AND ACCEPTABILITY OF PHARMACOLOGICAL TREATMENTS FOR ACUTE MANIA: A MULTIPLE-TREATMENTS META-ANALYSIS
PURGATO, Marianna
2011-01-01
Abstract
The main aim in treating mania, hypomania and mixed episodes is to achieve rapid control of symptoms. This is particularly important as mania can result in disturbed behavior that, when extreme, can be a risk to the safety of the patient and others. Mood stabilizers and antipsychotic agents have long been the mainstay of treatment of acute mania (with and without psychotic features). For clinical conditions where many treatment regimens already exist, competing with each other, the real question is how to rank their benefits (and harms) to choose the best option. This has led to the development of multiple treatments meta-analysis (MTM) that allow the incorporation of evidence from direct and indirect comparisons toward estimating summary treatment effects. The aim of this study is to compare the efficacy and acceptability of pharmacological treatments for acute mania, in order to inform clinical practice and mental health policies. We carried out a MTM. Reliable information on comparative efficacy is essential for informing clinical practice and policymaking and MTM allows us to use all the available evidence to estimate potential differences in efficacy among treatments.
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