The up- and down regulation of the response to a specific stimulatory compound, according to its doses and to sensitivity of the cells, is a widespread process in biology, immunology and endocrinology. This contribution describes the biological models and the in vitro evidence about the dose-response to formilpeptides in human neutrophils, assessing the cellular biology of the priming and the desensitization phenomena.
Dose-dependence of the various functional responses of neutrophils to formylpeptides
BELLAVITE, Paolo;CHIRUMBOLO, Salvatore;SANTONASTASO, Clara;
1997
Abstract
The up- and down regulation of the response to a specific stimulatory compound, according to its doses and to sensitivity of the cells, is a widespread process in biology, immunology and endocrinology. This contribution describes the biological models and the in vitro evidence about the dose-response to formilpeptides in human neutrophils, assessing the cellular biology of the priming and the desensitization phenomena.
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