Nitroaspirin (NCX-4016) was shown able to inhibit tissue factor expression in human monocytes, in the animal model of LPS-induced inflammation and ex vivo in monocuytes from NCX-4016 treated healthy subjects. Inhibition of tissue factor expression and activity may be additive to the antiplatelet and antithrombotic effects of aspirin.
Inhibition of TF expression on activated monocytes: potential role in the anti-thrombotic activity of NCX-4016
MENEGUZZI, Alessandra;LECHI, Alessandro;MINUZ, Pietro
2004-01-01
Abstract
Nitroaspirin (NCX-4016) was shown able to inhibit tissue factor expression in human monocytes, in the animal model of LPS-induced inflammation and ex vivo in monocuytes from NCX-4016 treated healthy subjects. Inhibition of tissue factor expression and activity may be additive to the antiplatelet and antithrombotic effects of aspirin.
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