Epigenetics refers to the study of heritable changes in gene expression that are not caused by DNA base changes and epigenetic gene regulatory mechanism is responsible for establishing and maintaining the diverse patterns of gene expression. Epigenetics is getting a higher attention to the molecular biologic field and now it is already regarded as critical mechanism for embryonic development, aging and carcinogenesis as well as it emerges to be a critical mechanism for chronic inflammation associated diesases. Interestingly, during our life nutrition influence this epigenetic gene regulation, indicating that nutrients can modulate those diseases associated with epigenetic phenomena. This book is compiled to update readers regarding the inter-relationships between nutrition, epigenetics. Epigenetic phenomena, such as DNA methylation, histone modifications, and chromatin remodeling, are newly emerging mechanisms with functions of gene expression modulation. Furthermore, since epigenetic events are potentially reversible, it is particularly interesting to consider that nutrients may prevent or possibly reverse disordered epigenetic phenomena associated with disease conditions. The book will address the latest information regarding the role of epigenetics on embryonic development, aging, and development of cancer as well as describe how nutrients affect those physiologic and pathologic processes through modulation of epigenetic phenomena. The importance of fostering future researches as well as highlighting new prospective in this specific field will also be emphasized.
Introduction to Nutrients and Epigenetics, chapter one
FRISO, Simonetta;
2009-01-01
Abstract
Epigenetics refers to the study of heritable changes in gene expression that are not caused by DNA base changes and epigenetic gene regulatory mechanism is responsible for establishing and maintaining the diverse patterns of gene expression. Epigenetics is getting a higher attention to the molecular biologic field and now it is already regarded as critical mechanism for embryonic development, aging and carcinogenesis as well as it emerges to be a critical mechanism for chronic inflammation associated diesases. Interestingly, during our life nutrition influence this epigenetic gene regulation, indicating that nutrients can modulate those diseases associated with epigenetic phenomena. This book is compiled to update readers regarding the inter-relationships between nutrition, epigenetics. Epigenetic phenomena, such as DNA methylation, histone modifications, and chromatin remodeling, are newly emerging mechanisms with functions of gene expression modulation. Furthermore, since epigenetic events are potentially reversible, it is particularly interesting to consider that nutrients may prevent or possibly reverse disordered epigenetic phenomena associated with disease conditions. The book will address the latest information regarding the role of epigenetics on embryonic development, aging, and development of cancer as well as describe how nutrients affect those physiologic and pathologic processes through modulation of epigenetic phenomena. The importance of fostering future researches as well as highlighting new prospective in this specific field will also be emphasized.
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