DNA methylation, a major epigenetic mechanism that fundamentally involved in cancer initiation, is now known to be responsible for: cancer progression, heterogeneous processes of cancer cell differentiation, mutations, and metastasis. During cancer progression this inheritable but reversible epigenetic phenomenon is involved in epigenetic silencing of critical genes, chromosomal instability, and differentiation of cancer stem cells. DNA methylation also interrelates with other epigenetic phenomena such as histone modifications, resulting in alteration of gene expression and cancer progression. This chapter updates the latest knowledge regarding the role of DNA methylation in cancer progression.
The role of DNA methylation in cancer progression
FRISO, Simonetta
2008-01-01
Abstract
DNA methylation, a major epigenetic mechanism that fundamentally involved in cancer initiation, is now known to be responsible for: cancer progression, heterogeneous processes of cancer cell differentiation, mutations, and metastasis. During cancer progression this inheritable but reversible epigenetic phenomenon is involved in epigenetic silencing of critical genes, chromosomal instability, and differentiation of cancer stem cells. DNA methylation also interrelates with other epigenetic phenomena such as histone modifications, resulting in alteration of gene expression and cancer progression. This chapter updates the latest knowledge regarding the role of DNA methylation in cancer progression.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
