Early research regarding the relationship between diet and cancer was based on the idea that cancer is caused by an overexposure to a specific diet. With a more clear understanding gained in recent years that cancer is a genetic disease, as shown by the molecular aberrations occurring in cancer cells, most of the studies have focused more specifically on the effect of particular nutrients on the expression of genes related to carcinogenesis. However, the presence of inherited mutations or defective genes is not sufficient to determine the phenotype, and finding aberrant genes does not guarantee, by itself, the onset of clinically manifested disease. Most recently, the complete mapping of the human genome and sophisticated molecular technologies have accelerated research on the relationship between nutrients and genes. Consequently, compelling evidence from epidemiological and experimental observations has suggested that the risk of certain cancers is different from one genotype of critical genes to another and has supported the idea that the interaction between nutrients and genes is one of the most important mechanisms by which nutrients modulate carcinogenesis. This book specifically focuses on the interrelationships between nutrients and genes in cancer, which, we believe, highlights that nutrients have not just one simple function in cancer development but, more notably, that nutrition is one of the most important factors, which serves as a modulator for cancer growth through the interaction with specific genes. A deeper understanding of such a relationship also has contributed to the detection of a new strategy for cancer chemoprevention. In this book we have endeavored to provide a comprehensive and systematic review of the latest information regarding the role of nutrients and genes interactions on cancer development, with the aim of also providing specific examples of well-known interactions 3229_C000.fm Page v Friday, September 23, 2005 11:46 AM between nutrients and genes with a defined pathogenetic role in clinical manifestations of different cancer diseases.

Preface

FRISO, Simonetta;
2006-01-01

Abstract

Early research regarding the relationship between diet and cancer was based on the idea that cancer is caused by an overexposure to a specific diet. With a more clear understanding gained in recent years that cancer is a genetic disease, as shown by the molecular aberrations occurring in cancer cells, most of the studies have focused more specifically on the effect of particular nutrients on the expression of genes related to carcinogenesis. However, the presence of inherited mutations or defective genes is not sufficient to determine the phenotype, and finding aberrant genes does not guarantee, by itself, the onset of clinically manifested disease. Most recently, the complete mapping of the human genome and sophisticated molecular technologies have accelerated research on the relationship between nutrients and genes. Consequently, compelling evidence from epidemiological and experimental observations has suggested that the risk of certain cancers is different from one genotype of critical genes to another and has supported the idea that the interaction between nutrients and genes is one of the most important mechanisms by which nutrients modulate carcinogenesis. This book specifically focuses on the interrelationships between nutrients and genes in cancer, which, we believe, highlights that nutrients have not just one simple function in cancer development but, more notably, that nutrition is one of the most important factors, which serves as a modulator for cancer growth through the interaction with specific genes. A deeper understanding of such a relationship also has contributed to the detection of a new strategy for cancer chemoprevention. In this book we have endeavored to provide a comprehensive and systematic review of the latest information regarding the role of nutrients and genes interactions on cancer development, with the aim of also providing specific examples of well-known interactions 3229_C000.fm Page v Friday, September 23, 2005 11:46 AM between nutrients and genes with a defined pathogenetic role in clinical manifestations of different cancer diseases.
2006
084933229X
9780849332296
gene-nutrient interactions; epigenetics; nutrition; genetics; cancer; carcinogenesis; folate; MTHFR; MTHFR polymorphism 677C>T; one-carbon metabolism; carotenoids; alcohol dehydrogenase polymorphism; alcohol associated carcinogenesis; brassica; ferritin; SHMT; SHMT polymorphism 1420 C>T; colorectal cancer; N-acetyltransferase gene; S-Adenosylmethionine; methionine adenosyltransferase; thymidilate synthase; methionine synthase; methionine synthase reductase; cystathione beta synthase; reduced folate carrier; hematopoietic malignancies; lung cancer
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/321126
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