Human skin is the largest organ of the body that provides a protective barrier to ensure that exogenous ‘noxious’ agents do not affect the homeostasis of the organism. Being situated at the interface between external and internal milieus, a number of remarkable structural and functional characteristics of skin have been delineated that contribute to its effectiveness at maintaining homeostasis. The skin has two main systems of defence. The ﬁrst is related to its physical and chemical properties, the other is the ‘immunological’ defence.
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