Hemostasis is a complex balance in which anticoagulant forces contribute to maintaining the fluidity of the blood within intact vessels and procoagulant forces act instead to avoid an excessive outflow of blood when the vessels lose their integrity. Hemostasis can be divided into primary, in which platelets and the vascular system play a key role, and secondary, in which coagulation factors participate. The subsequent fibrinolytic process has the function of bringing the vessel back to patency when the lesion has been repaired. This chapter will describe the main pathophysiological mechanisms of hemostasis and the related laboratory tests useful in the diagnosis and therapeutic monitoring of the main coagulation disorders.
Hemostasis
Lippi, Giuseppe;Salvagno, Gian Luca;
2023-01-01
Abstract
Hemostasis is a complex balance in which anticoagulant forces contribute to maintaining the fluidity of the blood within intact vessels and procoagulant forces act instead to avoid an excessive outflow of blood when the vessels lose their integrity. Hemostasis can be divided into primary, in which platelets and the vascular system play a key role, and secondary, in which coagulation factors participate. The subsequent fibrinolytic process has the function of bringing the vessel back to patency when the lesion has been repaired. This chapter will describe the main pathophysiological mechanisms of hemostasis and the related laboratory tests useful in the diagnosis and therapeutic monitoring of the main coagulation disorders.
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