The number of predictive biomarkers that will be necessary to assess in clinical practice will increase with the availability of drugs that target specific molecular alterations. Therefore, diagnostic laboratories are confronted with new challenges: costs, turn-around-time and the amount of material required for testing will increase with the number of tests performed on a sample. Our consortium of European clinical research laboratories set out to test if semi-conductor sequencing provides a solution for these challenges.

Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium

AMATO, Eliana;MAFFICINI, Andrea;SCARPA, Aldo;
2015-01-01

Abstract

The number of predictive biomarkers that will be necessary to assess in clinical practice will increase with the availability of drugs that target specific molecular alterations. Therefore, diagnostic laboratories are confronted with new challenges: costs, turn-around-time and the amount of material required for testing will increase with the number of tests performed on a sample. Our consortium of European clinical research laboratories set out to test if semi-conductor sequencing provides a solution for these challenges.
2015
Colonic Neoplasms; DNA Mutational Analysis; High-Throughput Nucleotide Sequencing; Humans; Lung Neoplasms; Multiplex Polymerase Chain Reaction; Mutation; Mutation Rate; Reproducibility of Results; Genotyping Techniques
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/935215
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