Lipids are essential for many biological processes and crucial in the pathogenesis of several diseases. The transport of such poorly water-soluble metabolites is often mediated by lipid-binding proteins. Understanding the chemistry of ligand binding to intracellular lipid carriers sets the basis for the development of new drugs.
Protein-mediated lipid transport: from molecular recognition to drug design
ASSFALG, Michael
2011-01-01
Abstract
Lipids are essential for many biological processes and crucial in the pathogenesis of several diseases. The transport of such poorly water-soluble metabolites is often mediated by lipid-binding proteins. Understanding the chemistry of ligand binding to intracellular lipid carriers sets the basis for the development of new drugs.
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