Host cell proteins are specifically incorpo- rated into HIV-1 envelope during budding. Virionic HLA- C reduces HIV-1 susceptibility to neutralizing antibodies (Cosma 1999). A polymorphism in the 5’ region of the HLA- C gene has been associated to individual variations in set point viral loads (Fellay 2007), suggesting a role of HLA-C expression levels in modulating HIV-1 infectivity. We have reported (Matucci 2008; Baroni 2010) that HLA-C in the HIV-1 envelope associates to Env increasing viral infectivity of both R5 and X4 tropic viruses. The purpose of this study is to elucidate this interaction and exploit it for generating new immunogens capable of conferring protective immunity.
HLA-C associates with Env and Increases HIV-1 infectivity
TURCI, Marco;RACCHIOLLI, Pierpaolo;ZIGLIO, Serena;ASTONE, Dalila;ZIPETO, Donato
2011-01-01
Abstract
Host cell proteins are specifically incorpo- rated into HIV-1 envelope during budding. Virionic HLA- C reduces HIV-1 susceptibility to neutralizing antibodies (Cosma 1999). A polymorphism in the 5’ region of the HLA- C gene has been associated to individual variations in set point viral loads (Fellay 2007), suggesting a role of HLA-C expression levels in modulating HIV-1 infectivity. We have reported (Matucci 2008; Baroni 2010) that HLA-C in the HIV-1 envelope associates to Env increasing viral infectivity of both R5 and X4 tropic viruses. The purpose of this study is to elucidate this interaction and exploit it for generating new immunogens capable of conferring protective immunity.
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