In the present work we classified using genetic signature two subgroups of human pancreatic tumors, based on the expression of ISGs and we demonstrated that this phenotype is indipendent from the microenvironment and is causing a resistance to oncolytic therapies.
Anti-viral state segregates two molecular phenotypes of pancreatic adenocarcinoma: Potential relevance for adenoviral gene therapy
V. Monsurro';BEGHELLI, Stefania;BARBI, Stefano;COIN, Silvia;BERSANI, Samantha;CASTELLUCCI, Monica;SORIO, Claudio;ELEUTERI, Stefano;PEDERZOLI, Paolo;SCARPA, Aldo
2009-01-01
Abstract
In the present work we classified using genetic signature two subgroups of human pancreatic tumors, based on the expression of ISGs and we demonstrated that this phenotype is indipendent from the microenvironment and is causing a resistance to oncolytic therapies.
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