Pancreatic neuroendocrine neoplasms (PanNENs) are tumors with neuroendocrine differentiation and are divided into functioning (syndromic) or non-functioning based on the clinical syndromes. Insulinomas are the most common functioning NETs. Non-functioning neuroendocrine tumors (NFNETs) account for up to 70–80% of all pancreatic NTEs. Pancreatic NFNETs are discovered incidentally or become clinically noticeable because of their large size. The diagnosis of pancreatic NENs is usually based on clinical and biochemical workup. Imaging is needed to localize the functioning tumor and characterize the non-functioning tumor providing local and distant staging.
Neuroendocrine Neoplasms
Riccardo De Robertis
;Mirko D’Onofrio
;Stefano Gobbo;Maria Gaia Mastrosimini;Lavinia Stefanizzi;Alessandro Beleù
;Luca Geraci
;Aldo Scarpa;
2022-01-01
Abstract
Pancreatic neuroendocrine neoplasms (PanNENs) are tumors with neuroendocrine differentiation and are divided into functioning (syndromic) or non-functioning based on the clinical syndromes. Insulinomas are the most common functioning NETs. Non-functioning neuroendocrine tumors (NFNETs) account for up to 70–80% of all pancreatic NTEs. Pancreatic NFNETs are discovered incidentally or become clinically noticeable because of their large size. The diagnosis of pancreatic NENs is usually based on clinical and biochemical workup. Imaging is needed to localize the functioning tumor and characterize the non-functioning tumor providing local and distant staging.
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