Chordoid is a rare variant of meningioma that displays a high recurrence rate. In this study we evaluated the immunohistochemical expression of factors that regulate the neo-angiogenesis process in a case of chordoid meningioma with an adverse clinical course. A high microvessel density (MVD), as well as high VEGF and VEGF-R1 expression, was encountered in this tumor. By contrast, the anti-angiogenic factor semaphorin3A, highly expressed in this chordoid meningioma, was ineffective because of the absence of its receptor neuropilin-1. We suggest that VEGF expression and MVD may represent significant prognostic factors in chordoid meningiomas.

Evaluation of neo-angiogenesis in a case of chordoid meningioma

Barresi V
Data Curation
2009-01-01

Abstract

Chordoid is a rare variant of meningioma that displays a high recurrence rate. In this study we evaluated the immunohistochemical expression of factors that regulate the neo-angiogenesis process in a case of chordoid meningioma with an adverse clinical course. A high microvessel density (MVD), as well as high VEGF and VEGF-R1 expression, was encountered in this tumor. By contrast, the anti-angiogenic factor semaphorin3A, highly expressed in this chordoid meningioma, was ineffective because of the absence of its receptor neuropilin-1. We suggest that VEGF expression and MVD may represent significant prognostic factors in chordoid meningiomas.
2009
Chordoid meningioma; Neo-angiogenesis; Endoglin; VEGF; Semaphorin3a; Neuropilin-1; Aged; Antigens, CD; Biopsy; Endoglin; Fatal Outcome; Humans; Male; Meningeal Neoplasms; Meningioma; Neovascularization, Pathologic; Neuropilin-1; Prognosis; Receptors, Cell Surface; Semaphorin-3A; Vascular Endothelial Growth Factor A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/986328
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