T-cell depleted HLA-haploidentical hematopoietic stem cell transplantation (HSCT) is a suitable option for patients in need of an allograft who lack a HLA-matched donor. Although it offers the advantage of being immediately applicable to virtually all patients, so far, graft manipulation with removal of all T lymphocyte subsets and of natural killer (NK) cells has been associated with an increased risk of life-threatening infections, as well as, in some studies, of leukemia recurrence.

Removal of alpha/beta+ T cells and of CD19+ B cells from the graft translates into rapid engraftment, absence of visceral graft-versus-host disease and low transplant-related mortality in children with acute leukemia given HLA-haploidentical hematopoietic stem cell transplantation

MORETTA, Francesca;
2013-01-01

Abstract

T-cell depleted HLA-haploidentical hematopoietic stem cell transplantation (HSCT) is a suitable option for patients in need of an allograft who lack a HLA-matched donor. Although it offers the advantage of being immediately applicable to virtually all patients, so far, graft manipulation with removal of all T lymphocyte subsets and of natural killer (NK) cells has been associated with an increased risk of life-threatening infections, as well as, in some studies, of leukemia recurrence.
2013
HLA-Haploidentical transplantation, Engraftment, Alpha/Beta+ T Cells, Acute leukemia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/936004
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