neutrophil-derived cytokines, FGF2, Ang1, IL-17, angiogenesis

Neutrophil-derived cytokines involved in physiological and pathological angiogenesis.

TECCHIO, Cristina;CASSATELLA, Marco Antonio
2014-01-01

Abstract

neutrophil-derived cytokines, FGF2, Ang1, IL-17, angiogenesis
2014
Increasing data from the literature point to a neutrophil-mediated role via cytokine production in several aspects of mammalian biology; including angiogenesis. In such regard; neutrophils have been shown to synthetize and release a number of molecules able to promote; directly or indirectly; the growth and migration of endothelial cells; in turn inducing the formation of new blood vessels from preexisting ones. Interestingly; neutrophil-derived cytokines can be involved either in physiological or in pathological angiogenesis; depending on either the functioning or dysregulation of sophisticated interplays among different cell types; extracellular matrix and soluble mediators within the microenvironment. Our review resumes the most interesting studies elucidating the role of neutrophil-derived cytokines in human physiological and pathological angiogenesis. When appropriate; supporting observations generated in animal models will be also mentioned. Particular emphasis will be given to VEGF and PK2/Bv8; rather than CXCL8/IL-8 and OSM. We will also discuss the potential role of neutrophil-derived cytokines such as FGF2; Ang1 and IL-17; whose roles in angiogenesis - albeit anticipated - remain to be elucidated.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11562/631954
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