Acantholytic dyskeratotic acanthoma in an immunosuppressed patient: a case report with review of the literature

Acantholytic dyskeratotic acanthoma (ADA) is a recently described benign acanthoma showing both acantholysis and dyskeratosis. Only 31 cases of ADA have been reported since the first description by Omulecki in 2007 in either the skin or the nails. We report an additional case seen in a 49-year-old Caucasian man receiving immunosuppressive therapy for a kidney allograft, who presented with a solitary keratotic lesion on the right calf. The cause of ADA as well as its relationship to other diseases and immunosuppression are unknown. We suggest that a decreased immune surveillance may have a role in its genesis.