We read with interest the recent report of Morris et al showing that lymphoid blast crises (BC) carry a preferential location of ABL/BCR breakpoints in the 3' part of the M-BCR. Fifty of 160 CML patients studied in our institutions underwent blast crisis during the period of observation. Diagnosis of BC type was done according to conventional morphologic, immunophenotypic, and cytochemical criteria. Phenotypically, 28were myeloid and 16were lymphoid with a myeloid/lymphoid (M:L) ratio of 1.75:l.The M:L ratioweobservedislowerthanthe3:lreported.' In44casesitwas possible to determine the BCR breakpoint subregion involved. No significant difference in the distribution and frequency of the two kinds of blast crisis among the different subregions.
BCR breakpoint subregions and blast crisis lineage in CML patients
MARTINELLI, Giovanni;PIGNATTI, Pierfranco;AMBROSETTI, Achille;
1992-01-01
Abstract
We read with interest the recent report of Morris et al showing that lymphoid blast crises (BC) carry a preferential location of ABL/BCR breakpoints in the 3' part of the M-BCR. Fifty of 160 CML patients studied in our institutions underwent blast crisis during the period of observation. Diagnosis of BC type was done according to conventional morphologic, immunophenotypic, and cytochemical criteria. Phenotypically, 28were myeloid and 16were lymphoid with a myeloid/lymphoid (M:L) ratio of 1.75:l.The M:L ratioweobservedislowerthanthe3:lreported.' In44casesitwas possible to determine the BCR breakpoint subregion involved. No significant difference in the distribution and frequency of the two kinds of blast crisis among the different subregions.
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