The distribution of calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) was investigated by the use of immunohistochemical techniques in the brain of young and aged rats. CGRP-like immunoreactivity (CGRP-LI) showed a significant decrease only in the amygdala, whereas a substantial age-dependent decrease in VIP-like immunoreactivity (VIP-LI) was observed in the cortex, amygdala, substantia nigra, hippocampus and suprachiasmatic nucleus.
On the effect of ageing on the distribution of vasoactive intestinal polypeptide and calcitonin gene-related peptide in the rat brain
FUMAGALLI, Guido Francesco;
1994-01-01
Abstract
The distribution of calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) was investigated by the use of immunohistochemical techniques in the brain of young and aged rats. CGRP-like immunoreactivity (CGRP-LI) showed a significant decrease only in the amygdala, whereas a substantial age-dependent decrease in VIP-like immunoreactivity (VIP-LI) was observed in the cortex, amygdala, substantia nigra, hippocampus and suprachiasmatic nucleus.
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