Despite a major decline in incidence and mortality, gastric cancer is still detected in around one million people every year and accounts for over 700,000 deaths, representing 8% of all cancer cases and 9.7% of all cancer deaths. The incidence is about twice as high in men as in women. In 2008, 60% of new cases occurred in Eastern Asia: 464,439 in China, 102,040 in Japan, and 27098 in South Korea. By comparison, new cases recorded in the European Union as a whole and throughout the United States were 83,120 and 21,499, respectively. High-incidence areas are East Asia, Eastern Europe, Central Asia, and the Pacific coast of South and Central America, while low-incidence areas are Western Europe, North America, Africa, and Australia. Likewise age-adjusted mortality is the highest in South Korea (30.7 and 11.3 per 100,000 person-years, respectively, in men and women in 2004) and the lowest in the USA (3.2 and 1.6 respectively). In Western countries, the decrease in the incidence of non-cardia gastric cancers parallels a concomitant increase in the incidence of gastric cardia cancer. Screening programs for gastric cancer are currently ongoing in Japan and South Korea. Two-thirds of Japanese patients survive beyond 5 years, while in Europe 5-year survival does not exceed 25%.
Epidemiology of gastric cancer and screening programs
VERLATO, Giuseppe;DE MANZONI, Giovanni
2011-01-01
Abstract
Despite a major decline in incidence and mortality, gastric cancer is still detected in around one million people every year and accounts for over 700,000 deaths, representing 8% of all cancer cases and 9.7% of all cancer deaths. The incidence is about twice as high in men as in women. In 2008, 60% of new cases occurred in Eastern Asia: 464,439 in China, 102,040 in Japan, and 27098 in South Korea. By comparison, new cases recorded in the European Union as a whole and throughout the United States were 83,120 and 21,499, respectively. High-incidence areas are East Asia, Eastern Europe, Central Asia, and the Pacific coast of South and Central America, while low-incidence areas are Western Europe, North America, Africa, and Australia. Likewise age-adjusted mortality is the highest in South Korea (30.7 and 11.3 per 100,000 person-years, respectively, in men and women in 2004) and the lowest in the USA (3.2 and 1.6 respectively). In Western countries, the decrease in the incidence of non-cardia gastric cancers parallels a concomitant increase in the incidence of gastric cardia cancer. Screening programs for gastric cancer are currently ongoing in Japan and South Korea. Two-thirds of Japanese patients survive beyond 5 years, while in Europe 5-year survival does not exceed 25%.
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