Viral vectors expressing humanized light and heavy IgG chains were produced by matching human constant regions with murine variable regions. Such viral vectors were used to coinfect CHO cells in order to obtain a cell line stably expressing humanized antibodies.
Viral vectors expressing humanized light and heavy IgG chains were produced by matching human constant regions with murine variable regions. Such viral vectors were used to coinfect CHO cells in order to obtain a cell line stably expressing humanized antibodies.
Humanization of murine neutralizing monoclonal antibodies against HIV-1 through a new approach based on lentiviral vectors
RACCHIOLLI, Pierpaolo
2011-01-01
Abstract
Viral vectors expressing humanized light and heavy IgG chains were produced by matching human constant regions with murine variable regions. Such viral vectors were used to coinfect CHO cells in order to obtain a cell line stably expressing humanized antibodies.
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